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Anti-cancer drug discovery against colorectal cancers by Resveratrol derivatives: a new-fangled computational approach.
Anti-cancer drug discovery against colorectal cancers by Resveratrol derivatives: a new-fangled computational approach.
Supervisor- Md. A. K. Azad
on going
Keywords: Drug design; Genistein; Breast cancer; Lung cancer; Glycyrrhiza glabra; Molecular docking; Molecular dynamics simulation.
Study of herbal combination for synbiotic effects on ulcer, hepatic function and lipid panel and an investigation on gastro-liver toxicity and sensible usage of PPI with mostly suggested respiratory drugs in Wister albino rats.
Study of herbal combination for synbiotic effects on ulcer, hepatic function and lipid panel and an investigation on gastro-liver toxicity and sensible usage of PPI with mostly suggested respiratory drugs in Wister albino rats.
Supervisor- Md. A. K. Azad
Keywords: Digestive System, Respiratory Drugs, Proton Pump Inhibitors, Herbal Medicine, Synbiotic Effect.
Abstract-Gastrointestinal problems and liver impairment are the most common disorders in the world. This current study targeted the adverse effects of respiratory drugs which can induce peptic ulcer disease and other problems of hepatic function and combination therapy as well as the beneficial effects of Amaranthus viridis & Yogurt combination GI system when ulcer was induced using indomethacin (30 mg/kg) , liver function and lipid profile and morphological characteristics of stomach was find out by using Dexamethasone, Montelukast, Rupatidine and Doxofylline multi drugs respectively by using spectrophotometry method on Wister albino rats for 14 days. For the investigation respiratory drugs Dexamethasone (0.5mg/kg), Montelukast (1.61 mg/kg)Rupatidine (1.41 mg/kg), Doxofylline (3.44 mg/kg) and for herbal therapy group (AV+ yogurt) 0.5 gm/kg were used throughout the total experiments .The SGPT level was within normal range as compared to the control (40.33 ± 1.76 IU/L) where the values for the herbal combination was 37 ± 4.04 IU/L. The herbal combination, however, notably effects lipid profiles and aids in keeping them within normal range. The lipid profiles for control groups were total cholesterol 68.67 ± 2.20 mg/ dl, triglycerides 124.07 ± 2.94 mg/dl, HDL 49.14 ± 1.05 mg/ dl, LDL54.11 ± 1.15 mg/dl respectively where the herbal combination group were 40.33 ± 2.60 mg/ dl, 109.67 ± 3.17 mg/dl, 40. 26 ± 0.89 mg/dl, 30.33 ± 1.56 mg/dl sequentially. A notable effect was seen compared to standard where the lipid profile for standard group, Triglycerides 47.7 ± 10.35 mg/dl, Total Cholesterol 42 ± 9.92 mg/dl, HDL 41 ± 5.70 mg/dl, LDL 26.8 ± 3.70 mg/dl respectively in which the reference of standard drug was atorvastatin ( 5mg/kg). In morphological investigation ulcer was formed in control group and slight inflammation was observed in standard group but there was no morphological changes in multi drug therapy and herbal combination group. So it is assumed that the herbal combination plays a great role in preventing GI disorders. So it can be said that no PPI is needed for these multiple drug therapy. Further investigation should be done to increase the validity of these statements.
Outcome-Throughout the investigation , the outcome is that the respiratory drugs has no adverse effect on liver function. The herbal combination has synbiotic effects on the body if regularly taken. And in case of liver function , herbal combination can play a great role. It can keep the lipid profile within normal range especially, LDL and triglycerides. As well as herbal combination ( AV+Yoghurt) has a great role in healing ulcer.
So outcome is that, using PPI and other drug along with respiratory drugs is absolutely irrational. So further investigation is needed about it.
Gastrointestinal tract and hepatic toxicity of mostly prescribed anti-diabetic multi drugs and effect of herbal combination remedy on ulcer induced Wister albino rats and rational use of PPI in Polypharmacy.
Gastrointestinal tract and hepatic toxicity of mostly prescribed anti-diabetic multi drugs and effect of herbal combination remedy on ulcer induced Wister albino rats and rational use of PPI in Polypharmacy.
Supervisor- Md. A. K. Azad
Keywords- Digestive System, Proton Pump Inhibitors, Anti- Diabetic Drugs, Herbal Medicine,
Abstract- The leading factor in global mortality is chronic illness. Worldwide, 29 million people died in 2002 from the four most common chronic diseases: diabetes, cancer, and cardiovascular disease. And to manage these chronic disorders a long term multiple drug therapy is required. And this multi drugs adversely affects our different organ of the body and this study particularly focused on anti- diabetic multi drug induced GI (Peptic ulcer disease) and disturbance of liver function. Gastrointestinal (GI) disorders include those that affect various portions of the GI tract as well as auxiliary digestive organs such as the liver, pancreas, and gallbladder. Drug induced peptic ulcer is one of the most common GI disorders. In this study most commonly prescribed anti- diabetic drugs were used on wister albino rats to see the effects on stomach lining and liver function for 14 days. And this study also investigated how the herbal plants Daucus carota raw powder, Musa paradisiaca Linn pulp powder, Carica papaya, Brassica oleracea var. capitata powder, and honey improve the stomach layer administered with indomethacin at a human dose and liver function. The drugs and sample were administered orally and after treatment period for biochemical test like SGPT, Lipid profile blood was collected and for morphological study the entire rats were sacrificed. From the study, it was found no significant changes were seen in morphological and biochemical results in anti-diabetic drug group rats with respect to control. The SGPT level was within the normal range of 37.20 ± 0.42 IU/L. On the other hand, marked changes were found in the sample group's lipid profile compared to the control group, with a promising result. The results for total cholesterol, triglyceride, HDL & LDL were 50.67 ± 1.76 (mg/dl), 102.33 ± 1.76 (mg/dl), 44.67 ±1.16 (mg/dl), 25.13 ± 0.68 (mg/dl) respectively.
Outcome-To treat this disease, multiple drugs are needed, and these multiple drugs have some side effects on the different parts of our body. This study was done to find out the effects of multiple anti-diabetic drugs on the stomach lining by doing a morphological study and liver function by investigating a biochemical parameter, SGPT. And no notable differences were found in SGPT levels against the control, with an unchanged morphology of the stomach layer rather than a red coloration in the control group. However, the herbal combination has a significant influence on lipid profiles and helps to maintain acceptable SGPT levels. This study also gave concern about the administration of multiple anti-diabetic drugs with misuse of anti- ulcerant drugs and their adverse effects on a patient and the rational use of this group of drugs. This research also suggest that the use of herbal medicine in patient with ulcer to minimize adverse effects of synthetic or semi- synthetic products.
Scientific Exploration of Anti-Allergic Herbal Remedies in Cow's milk induced Experimental Allergic Rats.
Scientific Exploration of Anti-Allergic Herbal Remedies in Cow's milk induced Experimental Allergic Rats.
Supervisor- Md. A. K. Azad
Key Words- Allergy, Anti- Allergic Drugs ,Serum IgE, Eosinophil, Herbal medication.
Abstract- Allergies are a group of chronic inflammatory illnesses caused by overreactions of the immune system to environmental chemicals known as allergens. Chemical allergens (such as those found in hair colors, skincare products, and perfumes), food allergens (such as genetically modified (GM) foods, tree nuts, peanuts, and eggs), and aeroallergens may all trigger a wide range of allergic responses (like dust mites, spores, and pollens). The goal of this research is to evaluate the effectiveness of common anti-allergic medications like Levocetirizine, Montelukast sodium,and Salbutamol against that of a variety of herbs, including garlic, ginger, tulsi, turmeric, and rosemary. Blood was drawn via cardiac puncture, and eosinophils and serum IgE were detected by spectrophotometry. Serum IgE levels in the herbal sample and standard groups were 315.6 ±51.121 and 219.33± 66.416 IU/ml, respectively, whereas the control group's IgE levels were 478 ±44.105 IU/ml. The eosinophil count in the herbal and conventional medicine groups was 0.97 ±0.033 and 1.27± 0.218 ( 103/L), respectively, whereas it was 1.87 ± 0.674 ( 103/L) in the placebo group. Skin and ocular morphology were studied to determine the efficacy of allergen induction.
Outcome-This study's objective is to compare the efficiency of conventional anti-allergy drugs like Levocetirizine, Montelukast sodium, and Salbutamol to that of certain herbs, such as garlic, ginger, tulsi, turmeric, and rosemary. There was a significant difference between the groups, with the control group having 478 ±44.105 IU/ml of IgE compared to the herbal sample group's 315.6± 51.121 IU/ml and the standard group's 219.33 ±66.416 IU/ml. In comparison to the placebo group's eosinophil count of 1.87 ±0.674 (103/L), those receiving herbal and conventional therapy had decreases of 0.97± 0.033 and 1.27± 0.218 (103/L), respectively. Animals in the control group had edema in the legs and face, and their eyes became a reddish tint, but such symptoms were missing in the standard and herbal sample groups. Therefore, these herbal plants do have the potential to reduce the likelihood of an allergic response, however further research is needed to confirm this.
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